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Biomarkers HCLS F2F 2009-11-03 Michael Miller.

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Presentation on theme: "Biomarkers HCLS F2F 2009-11-03 Michael Miller."— Presentation transcript:

1 Biomarkers HCLS F2F Michael Miller

2 Gene Expression Biomarker Definition
A set of sequences/genes/transcripts identified via some sequence database (Entrez Gene, GenBank, Affymetrix,…) Each sequences’ expression value An algorithm that allows a new gene expression profile to be matched against the Biomarker and produces a score

3 MammaPrint MammaPrint Figure 2 Nature 415, 530-536(31 January 2002)
doi: /415530a

4 GenSigDB http://compbio.dfci.harvard.edu/genesigdb/
Significant Gene Lists from PubMed Articles Does not include signatures Hosted by Dana Farber Cancer Institute

5 Challenges Gene Lists are embedded in articles
Often there is no clear algorithm included in articles to add new gene profiles

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