1. Cellular phenotype transformation occurs during thoracic aortic aneurysm development 
Jeffrey A. Jones, PhD, Juozas A. Zavadzkas, MD, Eileen I. Chang, BS, Nina Sheats, BS, Christine Koval, BS, Robert E. Stroud, MS, Francis G. Spinale, MD, PhD, John S. Ikonomidis, MD, PhD 
The Journal of Thoracic and Cardiovascular Surgery 
Volume 140, Issue 3, Pages (September 2010)
DOI: /j.jtcvs
Copyright © Terms and Conditions

2. Figure 1
Analysis of gene expression after cellular stimulation. Relative gene expression in normal and TAA fibroblast cell lines was analyzed in the absence (steady-state) or presence of biological stimuli. Cells were treated with 1nM ET-1, 100nM AngII, or 100nM PMA for 24hours and then analyzed by QPCR. Relative fold expression results were clustered in functional groups (MMP/TIMP, collagen/elastin, other ECM), and total gene expression was depicted as an area profile on a radar plot. Each axis displays the sum of the relative fold change in gene expression for a given gene cluster in the TAA fibroblasts compared with the control fibroblasts. MMP/TIMP, Matrix metalloproteinase/tissue inhibitor of metalloproteinase; TAA, thoracic aortic aneurysm; ECM, extracellular matrix; ET, endothelin; PMA, phorbol-12-myristate-13-acetate; AngII, angiotensin-II.
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs )
Copyright © Terms and Conditions