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Drug Survival Studies in Dermatology:Principles, Purposes, and Pitfalls
Juul M.P.A. van den Reek, Wietske Kievit, Robert Gniadecki, Jelle J. Goeman, Jeffrey Zweegers, Peter C.M. van de Kerkhof, Marieke M.B. Seyger, Elke M.G.J. de Jong Journal of Investigative Dermatology Volume 135, Issue 7, Pages 1-5 (July 2015) DOI: /jid Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 Melanoma-specific survival (log-rank P = 0.057).) Example of classic Kaplan–Meier survival curve (oncology). Kaplan–Meier survival analysis for cutaneous melanoma overall survival by 0, 1, 2, and 3/4 NUG (number of unfavorable genotypes). The steps (events) in this survival curve refer to the death of a patient (Yin et al., 2014). Journal of Investigative Dermatology , 1-5DOI: ( /jid ) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 2 Explanation of Kaplan–Meier drug survival curve. Kaplan–Meier drug survival analysis. Explanation of features of a drug survival curve. Journal of Investigative Dermatology , 1-5DOI: ( /jid ) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 3 Etanercept one-year drug survival (2005–2013) divided into four time frames. Kaplan–Meier drug survival analysis. Drug survival of etanercept, extracted from the BioCAPTURE registry, a Dutch daily practice biologics registry of psoriasis patients (van den Reek et al., 2014), divided for different time periods of initiation of etanercept. Historical occurrences thought to have had an influence on drug survival are described in the boxes. Journal of Investigative Dermatology , 1-5DOI: ( /jid ) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Journal of Investigative Dermatology 2015 135, 1-5DOI: (10. 1038/jid
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Journal of Investigative Dermatology 2015 135, 1-5DOI: (10. 1038/jid
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Journal of Investigative Dermatology 2015 135, 1-5DOI: (10. 1038/jid
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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