1. Facilitating the Design of Fluorinated Drugs
Klaus Müller, Hans-Joachim Böhm 
Chemistry & Biology 
Volume 16, Issue 11, Pages (November 2009)
DOI: /j.chembiol
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2. Figure 1 Chemical Structure of the Ligand tBuBrettPhos
This ligand was used in the studies by Watson et al. (2009).
Chemistry & Biology  , DOI: ( /j.chembiol )
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3. Figure 2
Typical Reaction Scheme for the Synthetic Method Developed by Watson et al. (2009).
Key advancements are the use of CsF as a source of fluorine and the biaryl monophospine tBuBrettPhos as a hydrophobic Pd-ligand for the regiospecific aryl fluorination by reductive elimination from ary-tBuBrettPhos-Pd(II)-F intermediates.
Chemistry & Biology  , DOI: ( /j.chembiol )
Copyright © 2009 Elsevier Ltd Terms and Conditions