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Published byAlbana Vigano Modified over 5 years ago
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Morphometric-stereological and functional epididymal alterations and a decrease in fertility in rats treated with finasteride and after a 30-day post-treatment recovery period Patrick Vianna Garcia, M.Sc., Mainara Ferreira Barbieri, B.Sc., Juliana Elaine Perobelli, M.Sc., Sílvio Roberto Consonni, M.Sc., Suzana de Fátima Paccola Mesquita, Ph.D., Wilma de Grava Kempinas, Ph.D., Luis Antonio Violin Pereira, M.D., Ph.D. Fertility and Sterility Volume 97, Issue 6, Pages (June 2012) DOI: /j.fertnstert Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 Schematic epididymis: segmentation for morphometric-stereological analysis (A) and serum DHT (B) and serum T (C) measurements in the control, finasteride, and 30 days post-treatment groups. ANOVA followed by the Tukey test to serum DHT measurements and ANOVA followed by the Bonferroni test to serum T measurements. bSignificantly different from the control group, P<.01. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 Photomicrographs of region 2 (proximal caput) of the epididymal caput (A–C) and transmission electron micrographs of region 2 of the epididymal caput (D–L). Control group (A, D, G, J), finasteride group (B, E, H, K), and 30 days post-treatment group (C, F, I, L). Note the reduction in the height of the secretory epithelium in the finasteride group (B, E) compared with in the control (A, D) and 30 days post-treatment (C, F) groups and the presence of basal (b) and principal (p) cells and stereocilia (s) in all groups (D–F). Cytoplasmic organelles (G–I) were apparent: Gc = golgi complex; M = mitochondria; Rer = rough endoplasmic reticulum (D–F); and Cj = cell junction complex, in all groups (J–L). Scale bars: 10 μm (A–C), 4 μm (D–F), 1,500 nm (G–I), and 500 nm (J–L). Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions
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