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Pathways to Primary Neurodegenerative Disease
John Hardy, PhD Mayo Clinic Proceedings Volume 74, Issue 8, Pages (August 1999) DOI: / Copyright © 1999 Mayo Foundation for Medical Education and Research Terms and Conditions
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Fig. 1 Proposed relationship among the various neurodegenerative diseases in terms of pathogenic pathways. The pathogenesis of 1 form of frontal temporal dementia, which is caused by mutations in the tau gene (FTDP-17),5,6 is shown in box I (orange) and box V (brown). The “typical” pathogenesis of Alzheimer disease is shown in box II (purple) and box V. However, Alzheimer disease frequently involves Lewy body pathology (box VI, blue). The pathogenesis of pure Lewy body diseases (including Parkinson disease) is shown in box III (green) and box VI. Besides mutations in the α-synuclein gene,4 loci leading to disease on chromosomes 2p’16 and 4p17 have recently been reported. The pathogenesis of prion diseases is shown in box IV (gold): some cases of prion disease have tangles, Lewy bodies, or both, and thus these cases include boxes V and VI, respectively. APP = amyloid precursor protein. Mayo Clinic Proceedings , DOI: ( / ) Copyright © 1999 Mayo Foundation for Medical Education and Research Terms and Conditions
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