1. RNA Interference in Mammals: The Virus Strikes Back
Bryan R. Cullen 
Immunity 
Volume 46, Issue 6, Pages (June 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1 Inhibition of RNAi by Viral Suppressors of RNA Interference
Qiu et al. (2017) propose that infection of cells by WT viruses results in the production of viral suppressors of RNA interference (VSR) proteins—A3, in the case of HEV71—that bind the dsRNA replication intermediate and block access by Dicer. In contrast, in the absence of the VSR, Dicer is able to access the dsRNA intermediate and cleave the dsRNA from the termini to generate vsiRNAs that inhibit viral replication. RdRP, viral RNA-dependent RNA polymerase.
Immunity  , DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions