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Volume 143, Issue 3, Pages e6 (September 2012)

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Presentation on theme: "Volume 143, Issue 3, Pages e6 (September 2012)"— Presentation transcript:

1 Volume 143, Issue 3, Pages 664-674.e6 (September 2012)
Levels of Gemcitabine Transport and Metabolism Proteins Predict Survival Times of Patients Treated With Gemcitabine for Pancreatic Adenocarcinoma  Raphaël Maréchal, Jean–Baptiste Bachet, John R. Mackey, Cécile Dalban, Pieter Demetter, Kathryn Graham, Anne Couvelard, Magali Svrcek, Armelle Bardier–Dupas, Pascal Hammel, Alain Sauvanet, Christophe Louvet, François Paye, Philippe Rougier, Christophe Penna, Thierry André, Charles Dumontet, Carol E. Cass, Lars Petter Jordheim, Eva–Laure Matera, Jean Closset, Isabelle Salmon, Jacques Devière, Jean–François Emile, Jean–Luc Van Laethem  Gastroenterology  Volume 143, Issue 3, Pages e6 (September 2012) DOI: /j.gastro Copyright © 2012 AGA Institute Terms and Conditions

2 Figure 1 Diagram of the selection and categorization of tumor specimens and patient populations. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2012 AGA Institute Terms and Conditions

3 Figure 2 Kaplan–Meier curves for OS of subgroups of patients with pancreatic cancer as a function of hENT1 and dCK abundance. Patients receiving (A) gemcitabine and (B) nongemcitabine treatment are represented. Patients at risk at 6-month intervals are indicated. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2012 AGA Institute Terms and Conditions

4 Figure 3 Kaplan–Meier curves for OS according to the abundance of hENT1 and dCK (hENT1 low, hENT1 moderate and any dCK, hENT1 low and dCK moderate/high, hENT1 high and dCK moderate/high). Patients at risk at 6-month intervals are indicated. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2012 AGA Institute Terms and Conditions

5 Supplementary Figure 1 Photomicrographs showing examples of PDAC with (A) high RRM1 expression, (B), low RRM1 expression, (C) no RRM1 expression, (D) high hENT1 expression, (E) moderate hENT1 expression, (F) low hENT1 expression, (G), high dCK expression, (H) moderate dCK expression, and (I) low dCK expression. Note positive expression in lymphocytes for hENT1 and dCK. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2012 AGA Institute Terms and Conditions


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