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Probability of IV antibiotic retreatment within thirty days is associated with duration and location of IV antibiotic treatment for pulmonary exacerbation in cystic fibrosis D.R. VanDevanter, P.A. Flume, N. Morris, M.W. Konstan Journal of Cystic Fibrosis Volume 15, Issue 6, Pages (November 2016) DOI: /j.jcf Copyright © 2016 The Authors Terms and Conditions
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Journal of Cystic Fibrosis 2016 15, 783-790DOI: (10. 1016/j. jcf. 2016
Copyright © 2016 The Authors Terms and Conditions
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Fig. 1 IV Antibiotic treatment durations, hospital admissions, and IV retreatment within 30days. Panel A) Distribution of IV antibiotic treatment durations. Black bars show numbers of patients of a given treatment duration who were never admitted to hospital as part of their exacerbation treatment. Panel B) Proportions of patients retreated with IV antibiotics within 30days of the end of exacerbation treatment by original IV treatment duration category (gray) or hospital admission category (white). Bars are 95% confidence intervals. Journal of Cystic Fibrosis , DOI: ( /j.jcf ) Copyright © 2016 The Authors Terms and Conditions
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Fig. 2 Logistic regression modeling of IV antibiotic retreatment within 30days using IV antibiotic treatment duration and hospital admission covariates. Open circles show univariate odds ratios of IV antibiotic retreatment. Closed circles show odds ratios derived from multivariate modeling that included CF Care Program and 13 other covariates previously shown to be significantly associated with elevated hazard of future pulmonary exacerbation (Table 2). Unadjusted odds ratios are shown above point estimates and adjusted odds ratios are shown below estimates. Bars show 95% confidence intervals. Journal of Cystic Fibrosis , DOI: ( /j.jcf ) Copyright © 2016 The Authors Terms and Conditions
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Fig. 3 Time-variation of covariate association with future exacerbation hazard from end of exacerbation treatment. Hazard ratios for future exacerbation (solid lines) and associated 95% confidence intervals (shaded areas) over the 6months immediately following IV antibiotic treatment cessation. Values are adjusted by inclusion of all covariates shown to be significantly associated with retreatment within 30days of end of exacerbation treatment. PEx=pulmonary exacerbation. Journal of Cystic Fibrosis , DOI: ( /j.jcf ) Copyright © 2016 The Authors Terms and Conditions
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