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Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. Bexarotene promotes PPARδ activation of target genes in mouse brain.

Published bySandra Evans Modified over 6 years ago

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Presentation on theme: "Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. Bexarotene promotes PPARδ activation of target genes in mouse brain."— Presentation transcript:

1 Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle.
Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. (A) We performed RT-PCR analysis to measure RNA expression of the PPARδ target genes Angptl4 and UCP2 in the cortex of 18-week-old nontransgenic control mice, vehicle-treated HD mice, and bexarotene-treated HD mice. **P < 0.01, ANOVA with post-hoc Tukey test. n = 9 to 12 mice per group. (B) We performed RT-PCR analysis of RNA expression of Angptl4 and UCP2 in the striatum of 18-week-old nontransgenic control mice, vehicle-treated HD mice, and bexarotene-treated HD mice. **P < 0.01, ANOVA with post-hoc Tukey test. n = 9 to 12 mice per group. (C) We performed RT-PCR analysis of RNA expression of five PPARδ target genes in the quadriceps muscle of 18-week-old nontransgenic control mice, vehicle-treated HD mice, and bexarotene-treated HD mice. ADFP, adipose differentiation–related protein; LPL, lipoprotein lipase; SCD1, stearoyl–coenzyme A desaturase 1. *P < 0.05, **P < 0.01, ANOVA with post-hoc Tukey test. n = 9 mice per group. Error bars represent SEM. Audrey S. Dickey et al., Sci Transl Med 2017;9:eaal2332 Published by AAAS

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