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Parkinson’s Disease: A Thalamostriatal Rebalancing Act?

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Presentation on theme: "Parkinson’s Disease: A Thalamostriatal Rebalancing Act?"— Presentation transcript:

1 Parkinson’s Disease: A Thalamostriatal Rebalancing Act?
Nicolas X. Tritsch, Adam G. Carter  Neuron  Volume 89, Issue 4, Pages (February 2016) DOI: /j.neuron Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Synaptic Rewiring
Dopamine depletion in a PD mouse model reduces the strength of thalamic inputs (orange), but not cortical inputs (green), onto dSPNs (red) compared to iSPNs (blue) in the striatum, unbalancing the “direct” and “indirect” pathways and thereby reducing movement. Neuron  , DOI: ( /j.neuron ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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