1. Measles Virus Takes a Two-Pronged Attack on PP1
Tsukasa Seya 
Cell Host & Microbe 
Volume 16, Issue 1, Pages 1-2 (July 2014)
DOI: /j.chom
Copyright © 2014 Elsevier Inc. Terms and Conditions

2. Figure 1
Measles Virus Subverts PP1-Mediated Dephosphorylation and Activation of RLRs
In response to viral RNA, PP1 dephosphorylates MDA5 (right) and RIG-I (left) to induce their activation, ultimately resulting in type I IFN production. However, measles virus (MV) subverts this response using two approaches. The MV-V protein acts as a competitive substrate for PP1 to block activation of MDA5. Additionally, the virus binds to the surface molecule DC-SIGN on dendritic cells and induces the activation of the Raf-1 kinase. Raf-1 phosphorylates the phosphatase inhibitor I-1, resulting in its association with GADD34-PP1 phosphatase holoenzymes and inhibition of their phosphatase activity.
Cell Host & Microbe  , 1-2DOI: ( /j.chom )
Copyright © 2014 Elsevier Inc. Terms and Conditions