1. Genes to Function to Therapeutics
PROTEIN-PROTEIN INTERACTIONS
Madhavi K. Ganapathiraju
Associate Professor
Department of Biomedical Informatics
University of Pittsburgh
Faculty of
Biomedical Informatics Training Program
Intelligent Systems Program
Joint CMU-Pitt Ph.D. Program in Comp Bio
Language Technologies Institute (CMU)
Informatics and Engineering for University of Pittsburgh

2. ? Protein-Protein Interactions Theme of Research in Madhavi’s Lab
Central to all biological processes and structural scaffolds
The network is a medium for systems biology research
But 90% of protein-protein interactions are unknown today ?
~22,500 protein-coding genes
Human Interactome
200,000 to 600,000 PPIs
protein-pairs
~250Million possible pairs
Theme of Research in Madhavi’s Lab
Discovery of protein-protein interactions from large data sources using Machine Learning methods
Results: 1000’s of Novel PPIs discovered Accurately
(c) Madhavi Ganapathiraju

3. Our work is focused on these 4 themes:
Predict novel PPIs,
Annotate and analyze PPIs for dissemination to biologists
And engage biologists and computer scientists to translate the PPIs

5. Electronics and Communications Engg
Recent Interests
Electronics and Communications Engg
Smart Lifestyle
IoT Enabled Sensors for Health
Stress Monitoring through Sensor Fusion
(c) Madhavi Ganapathiraju