1. Ibandronate conc in bone
Cortical Bone Prox Femur
Haversian canal
Trabecular Bone 8 4
0.4
0.2
1.0
0.5 *
MS/BS (%)
BFR/BV (mm2/mm2/y)
AF (/y)
0.4
0.2
0.0 4 2
Active area (mm2)
Labelled Surface (%)
Vertebrae
2000
1000
Ultimate load (N)
Femoral Neck *
Endocortical
MS/BS (%) 16 8 *
Ibandronate conc in bone 4
(ng/mg dry weight)
Tibia cortical bone
total prox diaph distal L6 vert
Adapted from Bone, 31:45-55, Copyright (2003), with permission from Elsevier.
Mean (SD)
* Denotes stat. signif.
Smith et al Bone 2003;32:45-55 1

2. Inner Transitional Zone
Trabecular
Compartment
Compact
cortex
Outer transitional
zone
Inner Transitional Zone
Bone 2014;59:173 (Fig. 2)
Reproduced from Bone, 59:173-9, Copyright (2014), with permission from Elsevier.
–2.0
–1.0
0.0
1.0 6 12
a,c
a,b,c,d b a
–1.5
–1.0
–0.5
0.0
0.5 6 12
a,c
a,b,c,d
a,b
–1.5
–1.0
–0.5
0.0
0.5 6 12
a,b,c,d
a,c
0.3
0.2
0.1
0.0
–0.1 6 12 a
a,c
a,b,c
a,b c

3. Reprinted from Am J Pathol, Vol 183, Andersen TL et al
Reprinted from Am J Pathol, Vol 183, Andersen TL et al., Understanding coupling between bone resorption and formation: are reversal cells the missing link?, Pages , Copyright (2013), with permission from Elsevier