Presentation is loading. Please wait.

Presentation is loading. Please wait.

Volume 375, Issue 9732, Pages (June 2010)

Similar presentations


Presentation on theme: "Volume 375, Issue 9732, Pages (June 2010)"— Presentation transcript:

1 Volume 375, Issue 9732, Pages 2143-2151 (June 2010)
Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study  Dr Ruth C Travis, DPhil, Gillian K Reeves, PhD, Jane Green, MD, Diana Bull, Sarah J Tipper, MSc, Krys Baker, Prof Valerie Beral, FRS, Prof Richard Peto, FRS, Prof John Bell, FRS, Diana Zelenika, PhD, Prof Mark Lathrop, PhD  The Lancet  Volume 375, Issue 9732, Pages (June 2010) DOI: /S (10) Copyright © 2010 Elsevier Ltd Terms and Conditions

2 Figure 1 Summary of findings for 12 SNPs in 7610 women with breast cancer and 10 196 randomly selected controls without breast cancer The Lancet  , DOI: ( /S (10) ) Copyright © 2010 Elsevier Ltd Terms and Conditions

3 Figure 2 Distribution of environmental risk factors for breast cancer by genotype Figure shows means or proportions and 95% CIs. Numbers do not always add up because of missing values. *Never users of hormone replacement therapy. †Conventional p values are shown in the figure; all p values are non-significant after adjustment for multiple testing, apart from that for rs by height, when adjusted p=0·01. †Insufficient data. The Lancet  , DOI: ( /S (10) ) Copyright © 2010 Elsevier Ltd Terms and Conditions

4 Figure 3 Per-allele relative risk (95% CI) of breast cancer by ten environmental risk factors for breast cancer Conventional p values are shown in the figure; all p values are non-significant after adjustment for multiple testing. HRT=hormone replacement therapy in postmenopausal women. *Never users of HRT. The Lancet  , DOI: ( /S (10) ) Copyright © 2010 Elsevier Ltd Terms and Conditions

5 Figure 4 Per-allele relative risk (95% CI) of oestrogen-receptor-positive breast cancer by use of hormone replacement therapy in postmenopausal women Conventional p values are shown in the figure; all p values are non-significant after adjustment for multiple testing. The Lancet  , DOI: ( /S (10) ) Copyright © 2010 Elsevier Ltd Terms and Conditions


Download ppt "Volume 375, Issue 9732, Pages (June 2010)"

Similar presentations


Ads by Google