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Relationship between Genotype and Phenotype

Published byΑντιγόνη Ζάρκος Modified over 6 years ago

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Presentation on theme: "Relationship between Genotype and Phenotype"— Presentation transcript:

1 Relationship between Genotype and Phenotype
Molecular Basis for Relationship between Genotype and Phenotype genotype DNA DNA sequence transcription RNA translation amino acid sequence protein function phenotype organism

2 Point Mutations on Gene Products

3 Mutation frequencies obtained with various mutagens in Neurospora
Mutagens are agents that cause mutations. Anything that is capable of causing chemical changes in the structure of DNA (especially bases) is a mutagen. Mutagens differ in mutagenicity.

4 The Ames Test Reveals Mutagenic Compounds
Strain 1 - frameshift mutation Strain 2 - base substitution

5 Revertant colonies per culture plate.
Ames Test Results1 Revertant colonies per culture plate. Treatment Control diethyl sulfate* ICR-191** TA1575 11 14,700 13 TA1578 25 450 TA1575 : his base substitution mutant TA1578 : his frameshift mutant * Highly toxic alkylating agent, occurs as colorless liquid with peppermint odor ** Acridine, colorless solid intercalating agent, known carcinogen 1 McCann et al., Proc. Natl. Acad. Sci. USA

6 Relationship between Genotype and Phenotype
Molecular Basis for Relationship between Genotype and Phenotype genotype DNA DNA sequence transcription RNA translation amino acid sequence protein function phenotype organism

7 Diploid Life Cycle vs. Haploid Life Cycle

8

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