1. Sorbitol transport in rat renal inner medullary interstitial cells
Jan B. Schüttert, G. Martin Fiedler, Clemens Grupp, Sabine Blaschke, R. Willi Grunewald 
Kidney International 
Volume 61, Issue 4, Pages (April 2002)
DOI: /j x
Copyright © 2002 International Society of Nephrology Terms and Conditions

2. Figure 1
Time course of sorbitol uptake. The results represent the means from seven experiments ± SD. Cells were incubated in HEPES-Ringer buffer containing a sorbitol concentration of 10 mmol/L. Neither aldose reductase nor sorbitol dehydrogenase was used. Symbols are: (♦) 37°C; (▪) 4°C. (Inset) Difference between the 4°C and 37°C experiments.
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

3. Figure 2
Concentration dependence. Sorbitol uptake in interstitial cells at different concentrations at with respect to sorbitol uptake at 80 mmol/L. Data are means ± SD. Cells were incubated at (♦) 37°C and (▪) 4°C in HEPES-Ringer buffer with aldose reductase inhibitor and sorbitol dehydrogenase inhibitor. (Inset) Difference between the 4°C and 37°C experiments after 15 minutes of incubation time.
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

4. Figure 3
Trans-stimulation experiments. Cells were preincubated with 50 mmol/L sorbitol (trans-stimulation) or 50 mmol/L mannitol for five hours. The uptake was measured after the preincubation time. Cells were incubated in HEPES-Ringer buffer with 1 mmol/L sorbitol for 15 minutes. Data show the increase in %± SD of five duplicate experiments after trans-stimulation with sorbitol. There was a significant increase (P < 0.05).
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

5. Figure 4
(A) Effects of phlorizin, phloretin, and 4-(chloromercuri)benzoesulfonic acid (pCMBS) on sorbitol uptake. Cells were incubated in HEPES-Ringer buffer for 15 minutes at 37°C; phlorizin, phloretin, and pCMBS were added in the given concentrations. (B) Effects of cytochalasin A and B on sorbitol uptake. The means of three experiments ± SD are shown. Symbols are: (□) controls; () experimental conditions; *P < 0.05, **P < 0.01 vs. control.
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

6. Figure 5
Uptake inhibition by cytochalasin B. Cells were incubated in 10 mmol/L sorbitol or 2-deoxy-D-glucose for 15 minutes. Cytochalasin B concentration was 0.01 mmol/L. The means of three experiments ± SD are shown; the difference of uptake inhibition was significant (P < 0.05). Symbols are: (□) controls; () experimental conditions.
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

7. Figure 6
Inhibition of sorbitol uptake. Cells were incubated in HEPES-Ringer buffer for 10 minutes at 37°C. The extracellular sorbitol concentration was 1 mmol/L and the concentration of the sorbitol analogues was 5 mmol/L. The means of three experiments ± SD are shown; *P < 0.01 vs. control. Abbreviations are: Glu-6-P, glucose-6-phosphate; So-6-P, sorbitol-6-phosphate.
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

8. Figure 6
Inhibition of sorbitol uptake. Cells were incubated in HEPES-Ringer buffer for 10 minutes at 37°C. The extracellular sorbitol concentration was 1 mmol/L and the concentration of the sorbitol analogues was 5 mmol/L. The means of three experiments ± SD are shown; *P < 0.01 vs. control. Abbreviations are: Glu-6-P, glucose-6-phosphate; So-6-P, sorbitol-6-phosphate.
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

9. Kidney International 2002 61, 1407-1415DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

10. Kidney International 2002 61, 1407-1415DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions