1. Volume 122, Issue 7, Pages 1800-1807 (June 2002)
Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus 
Christianne J. Buskens, Bastiaan P. van Rees, Anna Sivula, Johannes B. Reitsma, Caj Haglund, Piter J. Bosma, G.Johan A. Offerhaus, J.Jan B. van Lanschot, Ari Ristimäki 
Gastroenterology 
Volume 122, Issue 7, Pages (June 2002)
DOI: /gast
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2. Fig. 1
Representative examples of COX-2 immunohistochemistry. (A) Strong (3+) immunoreactivity in the tumor cells (Tu). Note that the nonneoplastic stroma (Str) including a blood vessel (BV) is negative. This tumor was categorized as COX-2 high (original magnification 200×). (B) Weak (1+) immunoreactivity in the tumor cells (Tu). The stroma (Str) is again negative. This tumor was categorized as COX-2 low (original magnification 200×). (C) Intestinal metaplasia (IM) that shows weak (1+) immunoreactivity. This specific sample expressed the highest intensity of metaplastic COX-2 positivity (original magnification 200×). (D) Strong (3+) immunoreactivity in the stromal cells (Str) at a site of an ulceration (original magnification 200×; stromal immunoreactivity was not scored). (E) Esophageal squamous epithelium (Sq) was either negative or weakly positive (1+; usually in the basal cells). The immunoreactivity of the tumor (Tu) in this specimen was scored as moderate (2+) and categorized as COX-2 high (original magnification 400×). Blocking controls for A–D are shown in a–d, respectively (see Patients and Methods for details).
Gastroenterology  , DOI: ( /gast )
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3. Fig. 2
Kaplan–Meier curves of 145 patients with esophageal Barrett's carcinoma. There were 30 patients with low COX-2 expression and 115 with high COX-2 expression. A statistically significant difference was observed between the 2 groups (P = 0.002; log-rank test).
Gastroenterology  , DOI: ( /gast )
Copyright © 2002 American Gastroenterological Association Terms and Conditions