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Pronociceptive Pain Modulation in Patients with Painful Chemotherapy-Induced Polyneuropathy  Hadas Nahman-Averbuch, MSc, David Yarnitsky, MD, PhD, Yelena.

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Presentation on theme: "Pronociceptive Pain Modulation in Patients with Painful Chemotherapy-Induced Polyneuropathy  Hadas Nahman-Averbuch, MSc, David Yarnitsky, MD, PhD, Yelena."— Presentation transcript:

1 Pronociceptive Pain Modulation in Patients with Painful Chemotherapy-Induced Polyneuropathy 
Hadas Nahman-Averbuch, MSc, David Yarnitsky, MD, PhD, Yelena Granovsky, PhD, Elliot Sprecher, PhD, Mariana Steiner, MD, Tzahala Tzuk-Shina, MD, Dorit Pud, PhD  Journal of Pain and Symptom Management  Volume 42, Issue 2, Pages (August 2011) DOI: /j.jpainsymman Copyright © 2011 U.S. Cancer Pain Relief Committee Terms and Conditions

2 Fig. 1 Correlations between clinical pain and experimental pain of the entire sample (n=27). Positive correlations were found between clinical pain and the mechanical temporal summation value (a) as well as with the CPM10 effect; (b) max pain=maximum pain intensity during the week before the experimental assessment; CPM10 effect=scorings of the conditioned test stimulus after 10 seconds minus scorings of the baseline test stimulus after 10 seconds. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2011 U.S. Cancer Pain Relief Committee Terms and Conditions

3 Fig. 2 Positive correlation between the mechanical temporal summation value and the CPM10 effect. CPM10 effect=scorings of the conditioned test stimulus after 10 seconds minus scorings of the baseline test stimulus after 10 seconds. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2011 U.S. Cancer Pain Relief Committee Terms and Conditions

4 Fig. 3 CPM effect along the stimulation period in the two patient groups. An interaction was found (P=0.03) between the two groups of patients in CPM time evolution, but no statistical difference was found at post hoc testing. Painful PNP=painful polyneuropathy patients; nonpainful PNP=nonpainful polyneuropathy patients. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2011 U.S. Cancer Pain Relief Committee Terms and Conditions


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