Presentation is loading. Please wait.

Presentation is loading. Please wait.

Comparison of Oral Prednisone and Topical Fluticasone in the Treatment of Eosinophilic Esophagitis: A Randomized Trial in Children  Elizabeth T. Schaefer,

Similar presentations


Presentation on theme: "Comparison of Oral Prednisone and Topical Fluticasone in the Treatment of Eosinophilic Esophagitis: A Randomized Trial in Children  Elizabeth T. Schaefer,"— Presentation transcript:

1 Comparison of Oral Prednisone and Topical Fluticasone in the Treatment of Eosinophilic Esophagitis: A Randomized Trial in Children  Elizabeth T. Schaefer, Joseph F. Fitzgerald, Jean P. Molleston, Joseph M. Croffie, Marian D. Pfefferkorn, Mark R. Corkins, Joel D. Lim, Steven J. Steiner, Sandeep K. Gupta  Clinical Gastroenterology and Hepatology  Volume 6, Issue 2, Pages (February 2008) DOI: /j.cgh Copyright © 2008 AGA Institute Terms and Conditions

2 Figure 1 Flow diagram of study participants. aSee Figure 2A. bSee Figure 2B. Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh ) Copyright © 2008 AGA Institute Terms and Conditions

3 Figure 2 (A) Flow diagram of subjects randomized to P. aNoncompliance with medication, n = 4; patient/family decision, n = 2; lost to follow-up evaluation, n = 1; adverse effect, n = 1 (increased appetite and abdominal pain). bBoth exited because of adverse effects, n = 2 (cushingoid, acne, behavioral changes). (B) Flow diagram of subjects randomized to F. aNoncompliance with medication, n = 2; patient/family decision, n = 2. bPersistence of symptoms, n = 1; asymptomatic, but no histologic improvement, n = 1. Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh ) Copyright © 2008 AGA Institute Terms and Conditions

4 Figure 3 Histology images of the distal esophagus at the (A) time of diagnosis and (B) after 4 weeks of F demonstrate basal cell hyperplasia comprising 75% of the epithelial thickness and eosinophil counts numbering 30 eos/hpf (40× objective, total 400× magnification), and normalization of epithelium after treatment (20× objective, total 200× magnification), respectively. Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh ) Copyright © 2008 AGA Institute Terms and Conditions

5 Figure 4 Kaplan–Meier curve showing proportion of symptom-free patients at each visit. Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh ) Copyright © 2008 AGA Institute Terms and Conditions


Download ppt "Comparison of Oral Prednisone and Topical Fluticasone in the Treatment of Eosinophilic Esophagitis: A Randomized Trial in Children  Elizabeth T. Schaefer,"

Similar presentations


Ads by Google