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Jay Kumar Singh, William E. Balch  Developmental Cell 

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1 Proteostatic Hotspots in Amyloid Fibrils Protect Us from Neurodegeneration 
Jay Kumar Singh, William E. Balch  Developmental Cell  Volume 32, Issue 6, Pages (March 2015) DOI: /j.devcel Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Proteostatic Hotspot Control of Native and Pathogenic Amyloid
Illustrated is the impact of designer amyloid chaperones (green, blue pentamers) on proteostatic hotspots (red stars) found in polymer fibrils assembled from monomers (black spheres) catalytically nucleating toxic oligomer formation. Therapeutic management of proteostatic hotspots triggering dementia may be treatable by hotspot-targeted therapeutics (orange chevrons). Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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