1. Hormones of the Pituitary Gland
01/01/2019
Dr. Omary Chillo (MD, PhD)

2. Dr. Omary Chillo (MD, PhD)
01/01/2019
Dr. Omary Chillo (MD, PhD)

3. Dr. Omary Chillo (MD, PhD)
Hypothalamus
Neuronal cells
Neuro
hypophysis
Epitheloid cells
Posterior Pituitary
Adeno
hypophysis
Anterior Pituitary
Pars intermedia
01/01/2019
Dr. Omary Chillo (MD, PhD)

4. The Anterior Pituitary cells and Hormones
Acidophils
Somatotropes GH
ACTH
TSH
FSH LH
PRL
Corticotropes
Thyrotropes
Gonadotropes
lactotropes
01/01/2019
Dr. Omary Chillo (MD, PhD)

5. The Posterior Pituitary cells and Hormones
Paraventricular neurones
Supraoptic neurones
Magnocellular Neurone
Posterior Pituitary
Oxytocin
ADH
01/01/2019
Dr. Omary Chillo (MD, PhD)

6. Hypothalamus controls pituitary secretions
Releasing or Inhibiting Hormones
Nerve Signals
01/01/2019
Dr. Omary Chillo (MD, PhD)

7. Hypothalamic-Hypophysial Portal System
01/01/2019
Dr. Omary Chillo (MD, PhD)

8. Hypothalamus Releasing/Inhibitory Hormones
Thyrotropin-releasing H (TRH)
TSH
Corticotropin-releasing H (CRH)
ACTH
GH-releasing H (GHRH) GH
GH-inhibiting H (Somatostatin) GH
Gonadotropin-releasing H (GnRH)
FSH LH
Prolactin-inhibitory H (PIH)
PRL
01/01/2019
Dr. Omary Chillo (MD, PhD)
Clip

9. Dr. Omary Chillo (MD, PhD)
Which kind of hormones from the anterior pituitary will be released following a removal of hypothalamus?
01/01/2019
Dr. Omary Chillo (MD, PhD)

10. Anterior Pituitary Hormones
TSH
CRH
Anterior Pituitary
FSH, LH
Prolactin
Growth Hormone
01/01/2019
Dr. Omary Chillo (MD, PhD)

11. The Growth Hormone Actions of Growth Hormone:
increase in cell size (hypertrophy)
increase in number of cells (hyperplasia)
Actions of Growth Hormone:
- increases skeletal growth
- increases muscular growth
- increases amino acid uptake and
protein synthesis
- increased use of lipids for energy
- decreased glucose uptake in tissues
(diabetogenic)
01/01/2019
Dr. Omary Chillo (MD, PhD)

12. Protein Deposition in Tissues
01/01/2019
Dr. Omary Chillo (MD, PhD)

13. Dr. Omary Chillo (MD, PhD)
01/01/2019
Dr. Omary Chillo (MD, PhD)

14. Dr. Omary Chillo (MD, PhD)
01/01/2019
Dr. Omary Chillo (MD, PhD)

15. Dr. Omary Chillo (MD, PhD)
01/01/2019
Dr. Omary Chillo (MD, PhD)

16. Regulation of GH release
GHRH
somatostatin Gs Gi
(-)
cAMP
PKA
PIT-1
GH synthesis
GH levels are low during the day, but increase during sleep.
There is an overall increase in GH levels during puberty.
01/01/2019
Dr. Omary Chillo (MD, PhD)

17. Abnormalities of Growth Hormone
Due to lack of GH release from the pituitary, or lack of GH receptor expression________
Excessive secretion of growth hormone________ and ________
? Growth Hormone effect on Aging
01/01/2019
Dr. Omary Chillo (MD, PhD)

18. The Posterior Pituitary cells and Hormones
Paraventricular neurones
Supraoptic neurones
Magnocellular Neurone
Posterior Pituitary
Oxytocin
ADH
01/01/2019
Dr. Omary Chillo (MD, PhD)

19. Dr. Omary Chillo (MD, PhD)
Thanks
01/01/2019
Dr. Omary Chillo (MD, PhD)