1. T Helper 17 Cells Get the NOD
Daniel B. Stetson, Ruslan Medzhitov 
Immunity 
Volume 27, Issue 4, Pages (October 2007)
DOI: /j.immuni
Copyright © 2007 Elsevier Inc. Terms and Conditions

2. Figure 1
NOD2 Activates Th17 Effector Function in Human Memory CD4+ T Cells
The pathway defined by van Beelen et al. (2007) reveals that NOD2 activation by MDP results in potent production of IL-1 and IL-23, which prime memory CD4+ T cells to produce IL-17. Important issues that remain to be explored include a mechanistic connection between NOD2 and caspase-1, possibly through the CARDs of these two proteins, and the signaling pathway that links NOD2 activation to transcription of IL-23 p19. It will also be interesting to determine whether NOD2 stimulation also activates a regulatory pathway to limit Th17 effector function.
Immunity  , DOI: ( /j.immuni )
Copyright © 2007 Elsevier Inc. Terms and Conditions