Presentation is loading. Please wait.

Presentation is loading. Please wait.

This Month in Gastroenterology

Similar presentations


Presentation on theme: "This Month in Gastroenterology"— Presentation transcript:

1 This Month in Gastroenterology
Jan Tack, John M. Carethers  Gastroenterology  Volume 136, Issue 7, Pages (June 2009) DOI: /j.gastro Copyright © 2009 AGA Institute Terms and Conditions

2 Figure 1 Proportion of patients in clinical remission at 3 and 6 weeks, shown as intention-to-treat (ITT) and per protocol (PP) analyses. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

3 Figure 2 Kaplan–Meier analysis of time to carcinoma for patients by (A) routine cytology result and (B) FISH result. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

4 Figure 3 Proposed model of negative feedback signaling in the intestinal epithelial crypt. Indian hedgehog (Ihh) secreted by differentiated cells acts on the myofibroblasts which secrete factors such as bone morphogenetic proteins (Bmp) that subsequently negatively regulate precursor cells at the base of the crypt. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

5 Figure 4 Efficient deletion of Dicer1 in young Albumin-Cre;Dicer1loxP/loxP mouse liver and repopulation with Dicer1-expressing hepatocytes. (A) Gross morphology of control and Albumin-Cre;Dicer1loxP/loxP mouse livers at 3, 6, and 12 weeks after birth. At 3 weeks, the Albumin-Cre;Dicer1loxP/loxP mouse liver was pale compared with the control. At 6 weeks, the Albumin-Cre;Dicer1loxP/loxP liver had become yellowish, with the appearance of normal-colored spots. The normal-colored areas had expanded at 12 weeks. (B) Quantitative polymerase chain reaction analysis of Cre transgene expression in Albumin-Cre;Dicer1loxP/loxP mouse liver. (C) Quantitative polymerase chain reaction analysis of Dicer1 expression. Dicer1 expression recovered with age. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions


Download ppt "This Month in Gastroenterology"

Similar presentations


Ads by Google