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Volume 141, Issue 5, Pages (November 2011)

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1 Volume 141, Issue 5, Pages 1792-1801 (November 2011)
Global and Deep Molecular Analysis of Microbiota Signatures in Fecal Samples From Patients With Irritable Bowel Syndrome  Mirjana Rajilić–Stojanović, Elena Biagi, Hans G.H.J. Heilig, Kajsa Kajander, Riina A. Kekkonen, Sebastian Tims, Willem M. de Vos  Gastroenterology  Volume 141, Issue 5, Pages (November 2011) DOI: /j.gastro Copyright © 2011 AGA Institute Terms and Conditions

2 Figure 1 Clustering of the HITChip phylogenetic profiles of the 108 fecal samples. Profiles of IBS patients and healthy controls are indicated with gray and black branches, respectively. The highest phylogenetic level of the probes' specificity is depicted on the right panel of the figure. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

3 Figure 2 Redundancy analysis plot of the microbiota composition of the 108 analyzed fecal samples as a function of the health status of analyzed subjects (healthy vs IBS). Samples of healthy controls are presented as black circles, while IBS patients are presented as gray rectangles (IBS-A, ■; IBS-C,♦; and IBS-D, ❚). Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

4 Figure 3 Redundancy analysis plot of the microbiota composition of 62 IBS patient fecal samples as a function of IBS symptom score. The phylogenetic groups that have contributed >20% to this plot are presented on the graph. The samples of the IBS patients are coded as in Figure 2. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

5 Figure 4 Phylogenetic tree representing the diversity of the human intestinal microbiota. The typical intestinal taxa are shown and presented in bold when found to be significantly different between IBS patients and healthy subjects and the direction of the change is indicated by the arrows (down arrow, higher in healthy; up arrow, higher in IBS). The reference bar indicates 10% sequence divergence. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions


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