1. Long-term effect of sodium hyaluronate (Hyalgan®) on osteoarthritis progression in a rabbit model 
D Amiel, Ph.D., T Toyoguchi, M.D., Ph.D., K Kobayashi, M.D., Ph.D., K Bowden, A.A., M.E Amiel, M.A., R.M Healey, B.S., M.B.A. 
Osteoarthritis and Cartilage 
Volume 11, Issue 9, Pages (September 2003)
DOI: /S (03)

2. Fig. 1
Experimental design. ACLT=no injections following anterior cruciate ligament transection (ACLT); 5 HA=five weekly injections of hyaluronan (HA) beginning on the 4th week after surgery; 5 PBS=five weekly PBS injections beginning on the 4th week after surgery; 10 HA=10 weekly HA injections, one course of five injections beginning on the 4th week after surgery and one course of five injections beginning on the 13th week after surgery; 10 PBS=10 weekly PBS injections, one course of five injections beginning on the 4th week after surgery and one course of five injections beginning on the 13th week after surgery.
Osteoarthritis and Cartilage  , DOI: ( /S (03) )

3. Fig. 2
Gross morphology of the meniscus in representative samples taken at 26 weeks after surgery from (a) Group 4 (10 HA+ACLT) and (b) Group 1 (ACLT only).
Osteoarthritis and Cartilage  , DOI: ( /S (03) )

4. Fig. 3
DNA concentration in synovium from medial femoral condyles (mean±SD). Results are shown for ACLT and non-ACLT (untreated) control knees for each study group. N=10 for each group.
Osteoarthritis and Cartilage  , DOI: ( /S (03) )

5. Fig. 4
Histomorphometric assessment of samples from the five treatment groups. (a) Cartilage height of the femoral condyles (mm) (mean±SD), (b) cartilage area of the femoral cartilage (mm2) (mean±SD), and (c) normalized cartilage roughness (RMS roughness/cartilage thickness) of the femoral cartilage (mm) (mean±SD). N=10 for each treatment group.
Osteoarthritis and Cartilage  , DOI: ( /S (03) )