1. Different effects of high molecular weight sodium hyaluronate and NSAID on the progression of the cartilage degeneration in rabbit OA model 
M. Mihara, Ph.D., S. Higo, B.S., Y. Uchiyama, M.S., K. Tanabe, M.S., K. Saito, Ph.D. 
Osteoarthritis and Cartilage 
Volume 15, Issue 5, Pages (May 2007)
DOI: /j.joca
Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
Protocol.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

3. Fig. 2
Weight distribution on left hind paw. Weight distribution on left hind paw was measured by Incapacitance Tester at 1–2 h after LOX administration. Each column and vertical line indicates the mean and SE of eight animals. The significant difference (or statistical analysis) between the value of each point and the value of Pre were analyzed using paired t test (*P<0.05).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

4. Fig. 3
Picture of a typical damaged joint. The damaged lesion consists of a white rough area having a coarse surface of the cartilage, and a hollow area with a pit in the cartilage tissue. Left lateral condyle of femur was covered by plastic wrap, and the area of damage was measured by tracing the area of injury. The traced paper was scanned into the computer, and then the area was measured by using the general-purpose image processing software.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

5. Fig. 4
Damaged area of joint cartilage. Each column and vertical line indicates the mean and SE of eight animals. The unpaired t test was used for the statistical analysis. The SVE group or the LOX group was compared with the control group (*P<0.05). The LOX+SVE group was compared with the LOX group (#P<0.05).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

6. Fig. 5
Histopathological score. Histopathological assessment was conducted according to the assessment criteria by Kikuchi et al. Each column and vertical line indicates the mean and SE of eight animals. For the statistical analysis, the Mann–Whitney U test was used. The SVE group or the LOX group was compared with the control group (*P<0.05). The LOX+SVE group was compared with the LOX group (#P<0.05).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

7. Fig. 6
Safranin-O unstained area. Safranin-O unstained area was measured using a 20× eyepiece micrometer and counting the reticules. Each column and vertical line indicates the mean and SE of eight animals. The unpaired t test was used for the statistical analysis. The SVE group or the LOX group was compared with the control group (*P<0.05). The LOX+SVE group was compared with the LOX group (#P<0.05).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

8. Fig. 7
Histology of cartilage. The injured femoral condyle was fixed in 10% formalin buffer (pH 7.4) containing 0.5% of cetylpyridinium chloride. After decalcification, the femoral condyle section was stained by Safranin-O. The pictures are representative of each group.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions