1. Office Hours: W 2-5pm Th 11am-2pm

2. Please answer the following questions:
I enjoy class. 4= Strongly Agree : 1= Strongly Disagree
Class is too fast, just right, too slow.
Class would be better if…

4. Development

5. Telomeres are non-gene DNA at the ends of DNA strands.
Telomeres are shortened during DNA replication, and by DNA damage.
Short telomeres will cause cell inactivity or cell death.
Telomere size is a measure of mutations.

6. Human
Life
Cycle
high levels of telomerase
very little telomerase

7. Control of gene expression is critical during development.

8. Cells function differently because they express different genes.

9. Vertebrate Development:
from zygote to adult

10. Besides adding cells, development can involve cell death.

11. Development of a mouse paw: yellow areas show dying cells
CB 21.19

12. Early embryo development
CB 21.4
Early embryo development

13. Totipotent: ability to differentiate into any cell-type

14. Totipotency is limited to early stages of animal development

15. Why do cells lose totipotency?
CB 21.6
Why do cells lose totipotency?

16. Why do cells lose totipotency?
CB 21.6
Why do cells lose totipotency?

17. Mature, differentiated plant cells are totipotent
CB 21.5
Mature, differentiated plant cells are totipotent

18. Why do cells lose totipotency?
CB 21.6
Why do cells lose totipotency?

19. CB 19.3
Gene expression can be controlled at many points between DNA and making the final proteins.
Changes in the various steps of gene expression control when and how much of a product are produced.

20. Why change gene expression? Different cells need different components
Responding to the environment
Replacement of damaged/worn-out parts CB
19.3

21. CB 19.2
Tightly packaged DNA is unavailable. DNA packaging changes as the need for different genes changes.

22. Normally DNA is loosely packaged
During mitosis DNA is tightly packaged as chromosomes and individually visible
CB12.6

23. DNA packaging fluctuates… genes being expressed are unpackaged, genes not needed are tightly packaged.

24. DNA packaging fluctuates… Some of the tightly packaging of DNA is irreversible.

25. Why do cells lose totipotency?
CB 21.6
Why do cells lose totipotency?

26. The proper control of gene expression is critical for proper development.

27. Down’s Syndrome is caused by an extra chromosome 21.
CB 15.15

28. Down’s Syndrome is caused by an extra chromosome 21.
Too much information disrupts normal development.
CB 15.15

29. The proper control of gene expression is critical for proper development.

30. Office Hours: W 2-5pm Th 11am-2pm