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Frederick J. Rubner, MD, Daniel J. Jackson, MD, Michael D

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1 Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence 
Frederick J. Rubner, MD, Daniel J. Jackson, MD, Michael D. Evans, MS, Ronald E. Gangnon, PhD, Christopher J. Tisler, MT, Tressa E. Pappas, BS, James E. Gern, MD, Robert F. Lemanske, MD  Journal of Allergy and Clinical Immunology  Volume 139, Issue 2, Pages (February 2017) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A and B, Impact of viral etiology on asthma risk at age 6, 8, 11, and 13 years. AdV, Adenovirus; CoV, coronaviruses; EV, enteroviruses; Flu, influenza types A and B; MpV, metapneumoviruses; PIV, parainfluenza virus types 1 to 4. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A, Identification of the role of timing of aeroallergen in asthma risk. B, Children sensitized by age 1 or 5 years had similar numbers of positive allergen sensitizations at age 13 years, but significantly more than children not sensitized by age 5 years. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Both aeroallergen sensitization and RV wheezing illnesses in the first 3 years of life increased asthma risk. The effects are additive and those children with both risk factors had the highest risk between age 6 and 13 years. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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