Download presentation
Presentation is loading. Please wait.
1
GENESDEV/2009/125252_Wu_ Supplemental Fig1
1.5 1 Heme Level * * 0.5 SA (mM):
2
GENESDEV/2009/125252_Wu_ Supplemental Fig2
SiRev-erb Rev-erb GSK3
3
GENESDEV/2009/125252_Wu_ Supplemental Fig3
PCDNA3.1 Rev-eb * 2 Fold Repression 1 Reporter: hPGC1-luc Rev-erb: B 2 PCDNA3.1 Rev-eb * Fold Repression 1 Rev-erb hPGC1-luc: WT RREpm RREdm RREp/dm
4
GENESDEV/2009/125252_Wu_ Supplemental Fig4
2.0 SiControl SiRev-eb 1.5 1.0 ChIP enrichment 0.5 Ab: HDAC Hsp90
5
GENESDEV/2009/125252_Wu_ Supplemental Fig5
shRNA HDAC3 b-actin B siRNA NCoR b-actin
6
GENESDEV/2009/125252_Wu_ Supplemental Fig6
3 * 2 PGC1 mRNA 1 Succinylacetone(mM): B 5 mRNA level DMSO 4 SA+DMSO SA+Heme 3 * * 2 1 PGC1 Bmal1 C Dex 1uM ETOH Heme PGC1a Rev-erba b-actin
7
Oxygen Consumption Rate
GENESDEV/2009/125252_Wu_ Supplemental Fig7 Control-3T3 Cells 1.5 1.0 Oxygen Consumption Rate Respiration-driven 0.5 DMSO Hemin (2.5M) 7
8
GENESDEV/2009/125252_Wu_ Supplemental Fig8
1.5 Rev-erb mRNA level 1.0 0.5 Day Day Day5
9
* * * * GENESDEV/2009/125252_Wu_ Supplemental Fig9 A B S (%)
10 8 S (%) * 6 * 4 2 Control-3T3 REV-3T31 REV-3T32 B 100 80 * * 60 G1(%) 40 20 Control-3T3 REV-3T31 REV-3T32
Similar presentations
© 2024 SlidePlayer.com. Inc.
All rights reserved.