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Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma.

Published byUte Böhmer Modified over 6 years ago

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Presentation on theme: "Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma."— Presentation transcript:

1 Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma model. Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma model. A, volumes of 21-day-old MC38-CEA tumors from 52 to 58 CEA-Tg mice per group from six independent experiments; Circles, individual measurements; bars, mean ± SEM. B, IHC of tumor sections harvested 21 days after tumor transplant from 3 mice per group analyzed for the T-cell marker CD3 (red-AF594) and the nuclear stain DAPI (blue). White arrows, CD3+ T lymphocytes; scale bars, 25 μm. C, number of intratumoral CD3 T lymphocytes/mm2. D, the percentage of CapM8 CEA–specific tumor-infiltrating CD8 T lymphocytes, calculated by flow cytometry. The number of HIV-GAG+ lymphocytes was subtracted from the total of CapM8 CEA-tetramer+ events; bars, mean ± SEM. Statistically significant difference based on ANOVA: *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < Benedetto Farsaci et al. Cancer Immunol Res 2014;2: ©2014 by American Association for Cancer Research

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