1. Macrophage Metabolism Shapes Angiogenesis in Tumors
Alberto Mantovani, Massimo Locati 
Cell Metabolism 
Volume 24, Issue 5, Pages (November 2016)
DOI: /j.cmet
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Impact of REDD1/mTOR-Mediated Control of Glycolysis in TAMs on Tumor Angiogenesis and Metastasization
(A) Hypoxia-induced REDD1 suppresses mTOR activity and inhibits glycolysis in TAMs, which leaves more glucose available for the endothelial cells. This results in the formation of a leaky vascular network that promotes metastasis.
(B) Targeting REDD1 in TAMs installs glucose competition and reduces endothelial glucose uptake, resulting in normalized blood vessel formation and reduced metastasis.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2016 Elsevier Inc. Terms and Conditions