1. Sharon Bates BSc (Hons) Research Midwife
Leicester’s Research Live – celebrating our success

2. Presentation Title 1 Title 2
Baby Biome Study: Obstetric & Midwifery Research Team Leicester’s Hospitals
Presentation Title 1
Title 2
Leicester’s Research Live – celebrating our success

3. Aims Background Aims Baby Biome study - success story
Leicester’s Research Live – celebrating our success

4. Background Approached by UCL in 2015 10,500 births per annum
Diverse population
Target 2000 recruits at UHL
19% of total population
Over a 22 month period
Three sites recruiting: BHRUT, UHL & UCHL
UHL recruited more than half of the total population
Leicester’s Research Live – celebrating our success

5. Study Type & Eligibility
Feasibility pilot study
Longitudinal cohort study
All women over 16 and all types of birth are eligible to participate
Leicester’s Research Live – celebrating our success

6. Study Aims
To find out how microbes and the immune system in early life work together to influence health in childhood and later life
Leicester’s Research Live – celebrating our success

7. Microbes Leicester’s Research Live – celebrating our success
As soon as we are born we are explosed to microbes. Some are benefical aiding food digestion and maintaining health, whilst others can cause illness. The immune system works defends against harmful microbes and illness.
However sometimes the immune system can cause illness itself. Like asthma, eczema, allergies & autoimmune diseases.
Baby Biome is looking at how microbes the immune system and clinical factors surrounding birth can influence health in children and later life.
Leicester’s Research Live – celebrating our success

8. Theories Leicester’s Research Live – celebrating our success
Baby Biome study is looking at the microbes and bacterial colonisation of the newborn gut.
Testing the theory that antibiotics given before during or after labour may affect the gut colonisation .
There are many variables with this study that could affect the microbe uptake such as :
type of birth : vaginal or caesarean section, or prolonged rupture of membranes and antibiotics given incl timing and doses.
Longitudinally they will look at these areas as predictors for future health and illness, for example asthma diabetes obesity using data linkage.
Leicester’s Research Live – celebrating our success

9. Sample Collection Vaginal swab prior to delivery
Maternal stool sample before or during delivery
Cord blood
Newborn stool samples
Woman were asked to donate waste samples
Mix & match number of samples women liked this.
Staff and patients nicknamed this “ The Poo Study “.
Many found it humourous that had to scoop the baby poop and post. Poor postman,
Leicester’s Research Live – celebrating our success

10. Total Recruits UHL managed to collect over …. %
Three sites recruiting: BHRUT, UHL & UCHL UHL recruited more than half of the total population
Here you can see Leicester was very successful with recruitment.
About 57%
Could be how we work as team and clinical staff involvement
Leicester’s Research Live – celebrating our success

11. Recruiting closed 30th Nov 2017
Recruiting closed 30th Nov Total number of participants recruited was an amazing Well done and thank you to all our women and colleagues for collecting the BBS samples
Some of you team & ladies 500 & 2011
Leicester’s Research Live – celebrating our success

12. Hot Topic BBC Radio 4 Approach Baby Biome for interviews.
The interviews will be part of a three part Science programme looking at Microbiome.
Air time : 10th, 17th, 24th April (11am).
Leicester’s Research Live – celebrating our success

13. Our Radio 4 Stars
Leicester’s Research Live – celebrating our success

14. Thanks to Research Midwives and Support Officers
Becky Pole & Natalie Clarke from CRN support.
Sally Batham & team in the Research Space
Clinical Staff UHL LRI & LGH
Antony Nolan Cord Collection Staff
Leicester’s Research Live – celebrating our success