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Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass  Masaki Funamoto, MD, Hidetoshi Masumoto, MD, PhD, Koji.

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Presentation on theme: "Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass  Masaki Funamoto, MD, Hidetoshi Masumoto, MD, PhD, Koji."— Presentation transcript:

1 Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass 
Masaki Funamoto, MD, Hidetoshi Masumoto, MD, PhD, Koji Takaori, MD, Tomofumi Taki, MD, Shuji Setozaki, MD, Kazuhiro Yamazaki, MD, PhD, Kenji Minakata, MD, PhD, Tadashi Ikeda, MD, PhD, Suong-Hyu Hyon, PhD, Ryuzo Sakata, MD, PhD  The Annals of Thoracic Surgery  Volume 101, Issue 4, Pages (April 2016) DOI: /j.athoracsur Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Study protocol. (CPB = cardiopulmonary bypass; EGCG = epigallocatechin-3-gallate; T-pre, T-cpb, and T-post = time for arterial blood sampling before, during, and 1 hour after CPB; T-24h = sacrifice and assessment at 24 hours after CPB.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Biochemical measurements and markers of acute kidney injury. (A) Serum creatinine. (B) Serum neutrophil gelatinase-associated lipocalin (NGAL). (C) Messenger RNA (mRNA) expression of kidney injury molecule-1 (Kim-1) in renal tissues. All values are means ± standard deviation. *p < 0.05 vs sham, †p < 0.01 vs sham, §p < vs sham; ||p < 0.05 vs CPB, ††p < vs CPB. (CPB = cardiopulmonary bypass; EGCG = epigallocatechin-3-gallate.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Immunohistologic findings of kidney injury molecule-1 (Kim-1) for cardiopulmonary bypass (CPB) and epigallocatechin-3-gallate (EGCG) groups. Scale bar, 50 μm. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Periodic acid-Schiff (PAS) staining for sham, for cardiopulmonary bypass (CPB), and epigallocatechin-3-gallate (EGCG) groups. Scale bar, 50 μm. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Histologic analysis and oxidative stress in sham, cardiopulmonary bypass (CPB), and epigallocatechin-3-gallate (EGCG) groups. (A) Tubular injury score, 0 = no tubular injury; 1 = less than 10%; 2 = 10% to 25%; 3 = 26% to 50%; 4 = 51% to 75%; 5 = more than 75% of tubules injured. (B) Staining ratio for 8-hydroxy-2′-deoxyguanosine (8-OHdG) showing the number of the 8-OHdG–stained cells/total tubular cells. (C) Messenger RNA (mRNA) expression of hemoxygenase-1 (HO-1) in renal tissues. All values are means ± standard deviation. ‡p < vs sham, §p < vs sham; ||p < 0.05 vs CPB, #p < 0.01 vs CPB, **p < vs CPB. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Immunohistological findings of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in sham, cardiopulmonary bypass (CPB) and epigallocatechin-3-gallate (EGCG) groups. Scale bar, 50 μm. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

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