1. Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition 
Isabel R.V. Hartwig, MSc, Peter D. Sly, MD, Louis A. Schmidt, PhD, Ryan J. van Lieshout, MD, PhD, John Bienenstock, MD, Patrick G. Holt, PhD, Petra C. Arck, MD 
Journal of Allergy and Clinical Immunology 
Volume 134, Issue 1, Pages e7 (July 2014)
DOI: /j.jaci
Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
A differential diagnosis of the atopic diseases asthma, rhinitis, and eczema in the study population and frequency of nonatopic and atopic asthma among children in response to prenatal life events. A, Prevalence of asthma in children at age 6 years and age 14 years; the percentages relate to the population with or without a diagnosis at age 6 years. B, The frequency of children with atopic or nonatopic asthma at age 14 years, depicted in response to number (n) of prenatal life events that occurred between gestational weeks 18 and 34. *Indicates significant adjusted OR of 1.52 (95% CI: ) for atopic asthma in children of mothers who had 1 life event compared with those with no life events. These results were derived from a post hoc multinomial regression analysis adjusted for confounders. The numbers below the life event categories show the total number of children with asthma (atopic and nonatopic) per total number of children within category. C, Prevalence of allergic rhinitis in children at age 6 years and age 14 years; the percentages relate to the population with or without diagnosis at age 6 years. D, The prevalence of eczema in children at age 6 years and age 14 years. The percentages relate to the population with or without a diagnosis at age 6 years.
Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci )
Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig E1
Number of children with 1 or multiple atopic diseases at age 6 years (A) and 14 years (B). Percentages relate to the parent population. Children with 3 atopic diseases, with asthma, allergic rhinitis, and eczema.
Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci )
Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions