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More Chores for TOR: De Novo Ceramide Synthesis

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Presentation on theme: "More Chores for TOR: De Novo Ceramide Synthesis"— Presentation transcript:

1 More Chores for TOR: De Novo Ceramide Synthesis
Robert C. Dickson  Cell Metabolism  Volume 7, Issue 2, Pages (February 2008) DOI: /j.cmet Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 De Novo Ceramide and Sphingolipid Synthesis Is Regulated by TORC2 in Yeast Initial steps in sphingolipid synthesis up through formation of dihydroceramide are fairly well conserved in eukaryotes including the baker's yeast Saccharomyces cerevisiae and mammals. TORC2 in yeast senses growth signals and activates the protein kinase Ypk2, which then activates ceramide synthase. The Ca2+/calmodulin-regulated protein phosphatase calcineurin opposes the TORC2-Ypk2 pathway to downregulate ceramide synthase activity. Cell Metabolism 2008 7, DOI: ( /j.cmet ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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