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In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donor-Recipient Pairs  Maximilian Jameson-Lee,

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Presentation on theme: "In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donor-Recipient Pairs  Maximilian Jameson-Lee,"— Presentation transcript:

1 In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donor-Recipient Pairs  Maximilian Jameson-Lee, PhD, Vishal N. Koparde, PhD, Juliana K. Sampson, PhD, Allison F. Scalora, MS, Haniya Khalid, BS, Nihar Sheth, MS, Phil Griffith, MS, Myrna G. Serrano, PhD, Vladimir Lee, PhD, Catherine H. Roberts, PhD, Michael C. Neale, PhD, Gregory A. Buck, PhD, Masoud Manjili, PhD, Amir Ahmed Toor, MD  Biology of Blood and Marrow Transplantation  Volume 20, Issue 2, Pages S269-S270 (February 2014) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 Comparison of total number of SNP (WES) in each DRP, in silico derived nona-peptides with strong binding (IC50 <50 nm) and strong-week binding (IC50 <500 nM). Biology of Blood and Marrow Transplantation  , S269-S270DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 IC50 values of peptide-HLA complexes for MRD (red) URD (blue) for IC50 < 500nm. Data for a single allele presented. Peptides below the black line are strong binding (IC50 <50 nm). Biology of Blood and Marrow Transplantation  , S269-S270DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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