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Centromeres of a Different CAL-ibre

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Presentation on theme: "Centromeres of a Different CAL-ibre"— Presentation transcript:

1 Centromeres of a Different CAL-ibre
Ewelina Zasadzińska, Daniel R. Foltz  Developmental Cell  Volume 37, Issue 2, Pages (April 2016) DOI: /j.devcel Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Co-evolution of CENP-A and CAL1 in the Drosophila Lineage
CENP-A histones from other Drosophila species are partially or completely incapable of being recruited to D. melanogaster centromeres. Efficient deposition of CENP-A nucleosomes requires the right combination of species-matched CAL1 and CENP-A. Endogenous D. melanogaster CAL1 can interact with exogenous D. bipectinata CENP-A; however, this interaction is not sufficient to facilitate bipectinata CENP-A deposition in D. melanogaster cells. Deposition of bipectinata CENP-A requires co-expression of bipectinata CAL1 in D. melanogaster cells. In contrast, the essential CENP-C and CAL1 interaction required for centromeric targeting of the complex does not co-evolve, but is well conserved across Drosophila lineages. The species-specific compatible CENP-A and CAL1 complexes are depicted by different colors. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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