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ABT-199: Taking Dead Aim at BCL-2

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Presentation on theme: "ABT-199: Taking Dead Aim at BCL-2"— Presentation transcript:

1 ABT-199: Taking Dead Aim at BCL-2
Matthew S. Davids, Anthony Letai  Cancer Cell  Volume 23, Issue 2, Pages (February 2013) DOI: /j.ccr Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 ABT-199 Selectively Kills BCL-2-Dependent Tumor Cells While Sparing Platelets (A) Navitoclax (ABT-263) binds with high affinity to both BCL-2 and BCL-XL. Because many tumors, particularly lymphoid malignancies, are addicted to BCL-2 for survival, this potently induces tumor cell apoptosis. Platelets depend primarily on BCL-XL for survival and, therefore, are also destroyed by navitoclax. (B) ABT-199 is specific for BCL-2 and induces selective death of BCL-2 dependent tumor cells while sparing platelets. Figure created by Richard Oakley. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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