1. Cling-E. coli : Bacteria on target
Harvard iGEM 2007
Ellenor Brown
Stephanie Lo
Alex Pickett
Sammy Sambu
Kevin Shee
Perry Tsai
Shaunak Vankudre
George Xu

2. The motivation
To develop a system for directing bacteria to a target of interest and effecting downstream activity
Bacterial targeting is necessary for spatially-specific activity in the body or in nature
Post-targeting activity and transmembrane signalling are the next step in engineering genetic circuits that interface extracellular and intracellular environments

3. The vision: Bacterial targeting
via membrane display

4. The vision: Inter-cellular activation via Lux quorum-sensing

5. The vision: Intra-cellular activation via Fec signal transduction