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Figure 4 Expression of type 1 IFN cytokines in different aDM subtypes

Published byIwan Sukarno Kusumo Modified over 6 years ago

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Presentation on theme: "Figure 4 Expression of type 1 IFN cytokines in different aDM subtypes"— Presentation transcript:

1 Figure 4 Expression of type 1 IFN cytokines in different aDM subtypes
Expression of type 1 IFN cytokines in different aDM subtypes CD23+ B cells are a source of CXCL13 as indicated by double immunofluorescent staining (A, arrowheads). Gene expression of CXCL12 and CXCL13 was illustrated by the log10 of fold change values compared with the normal controls. Results show mean ± SEM. *p < 0.05, **p < (B) EM revealed tubuloreticular inclusions (arrowheads) in the cytoplasm of a B-lymphocyte (solid and dashed boxes indicate magnified areas; * = mitochondrion). MxA staining revealed strong expression in the perifascicular area on myofibers and capillaries (C, arrows) in all cases and additional expression by B cells in B-cell–rich and follicle-like aDM (C, arrowheads). In contrast to healthy controls, muscle fibers of different DM subgroups showed upregulation of ISG20 (D; CRTL: normal control). aDM = adult dermatomyositis; DM = dermatomyositis; IFN = interferon; IM = intramuscular; ISG = interferon-stimulated gene; MxA = myxovirus resistance gene A; n = nucleus. Josefine Radke et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e451 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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