1. Metabolic Energy
Dr. Kevin Ahern

2. Metabolic Energy

3. Metabolic Energy

4. Metabolic Energy

5. ∆G = ∆G°’ + RTln([B]b/[A]a) For aA + cC ⇄ bB + dD
Metabolic Energy
For aA ⇄ bB
∆G = ∆G°’ + RTln([B]b/[A]a)
For aA + cC ⇄ bB + dD
∆G = ∆G°’ + RTln{([B]b[D]d)/([A]a[C]c)}
∆G = ∆G°’ + RTln({Products}/{Reactants})

6. if ΔG is negative, A->B is favored
Metabolic Energy
For A <=> B
if ΔG is negative, A->B is favored
if ΔG is positive, B-> A is favored
if ΔG is 0, B-> A and A-> B are equally favored
At ΔG = 0, the system is at equilibrium

7. Creatine + ATP <=> Creatine Phosphate + ADP
Metabolic Energy
Muscle Energy
Creatine Kinase
Creatine + ATP <=> Creatine Phosphate + ADP
ΔG0' = +12 kJ/mol

8. Metabolic Energy

9. Metabolic Energy

10. Metabolic Energy

11. Metabolic Energy
Nicotinamide
Dinucleotide
Adenine

12. Metabolic Energy Coupled Reactions
Glucose + Pi <=> Glucose-6-Phosphate ΔG°’ = +14 kJ/mol
Glucose + ATP <=> Glucose-6-Phosphate ΔG°’ = kJ/mol

13. Metabolic Pathways

14. Metabolic Pathways

15. Metabolic Pathways

16. Metabolic Pathways

17. ΔG°’ Values of Hydrolysis (kJ/mol)
Metabolic Pathways
ΔG°’ Values of Hydrolysis (kJ/mol)
PEP = -61.9
1,3 BPG = -49.4
Creatine Phosphate = -43.1
ATP to ADP = -30.5
G1P = -20.9
Pyrophosphate = -19.3

18. Oh Delta G (To the tune of "Oh Danny Boy") Copyright Kevin Ahern
Metabolic Melodies
Oh Delta G - the change in Gibbs free energy Can tell us if a process will advance 'Cause if the value's less than naught it translates that Reverse reactions haven't got a chance
But when the sign is plus it is the opposite And then the backwards happens all the time A factor is the standard Gibbs free energy So don't forget about the delta G naught prime

19. The Muscle Energy Song Metabolic Melodies For running and for jumping
(to the tune of “I Will”)
Copyright © Kevin Ahern
Metabolic Melodies
For running and for jumping
You need some energy
Chemically the body stores it
In the form of ATP
If backup should be needed
Reserves are there in wait
Muscles brimming with supplies of
Tiny creatine phosphate
Ready whenever cells are ever
Needing to exercise
Steady as ever when whatever
Energy needs arise
The action is exacting
For leaping in the air
Myofibrils all contracted
Using energy extracted
From reactions that react in me
Using A-T-P
You see