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A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial  Richard H.

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Presentation on theme: "A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial  Richard H."— Presentation transcript:

1 A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial  Richard H. Reindollar, M.D., Meredith M. Regan, Sc.D., Peter J. Neumann, Sc.D., Bat-Sheva Levine, M.D., Kim L. Thornton, M.D., Michael M. Alper, M.D., Marlene B. Goldman, Sc.D.  Fertility and Sterility  Volume 94, Issue 3, Pages (August 2010) DOI: /j.fertnstert Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Screening and Enrollment of Infertile Couples. ∗ 86 couples chose to discontinue treatment after a median of 4.5 cycles (interquartile range, 3 to 6 cycles) over a median duration of 8 months (interquartile range, 3 to 15 months). † The median duration of follow-up for these couples was 6 months (interquartile range, 3 to 14 months) and was 14 months (interquartile range, 11 to 18 months) among couples who completed follow-up. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Kaplan-Meier Estimates of Cumulative Incidence of Pregnancy Leading to Delivery of a Live Born, According to Treatment Arm. HR = (95% CI, 1.00 to 1.56; log rank P = ). Analysis also used a piecewise Cox proportional hazards model, overall P = Out of 106 couples who had their IUI prior to the date of randomization (but before pregnancy could be determined), 15 (3/50 conventional and 12/56 accelerated) became pregnant. Additionally, 4 couples in the accelerated arm became pregnant before initiating their first treatment cycle. These couples are shown as achieving pregnancy on day of randomization. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions


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