1. Stressed-Out HSCs Turn Up p38α and Purine to Proliferate
Marieke A.G. Essers 
Cell Stem Cell 
Volume 19, Issue 2, Pages (August 2016)
DOI: /j.stem
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
p38α Induced Activation of Purine Metabolism in HSCs under Stress Conditions
Upon transplantation, p38α becomes phosphorylated and activated in engrafting HSCs. Activation of the p38MAPK pathway then leads to an increase in the transcription factor Mitf, inducing transcription of genes coding for purine-related enzymes such as Impdh2. This leads to elevated purine metabolism in stressed HSCs, promoting their proliferation to ensure efficient bone marrow repopulation by stressed HSCs.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2016 Elsevier Inc. Terms and Conditions