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Osteoimmunology in mucopolysaccharidoses type I, II, VI and VII

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Presentation on theme: "Osteoimmunology in mucopolysaccharidoses type I, II, VI and VII"— Presentation transcript:

1 Osteoimmunology in mucopolysaccharidoses type I, II, VI and VII
Osteoimmunology in mucopolysaccharidoses type I, II, VI and VII. Immunological regulation of the osteoarticular system in the course of metabolic inflammation  V. Opoka-Winiarska, A. Jurecka, A. Emeryk, A. Tylki-Szymańska  Osteoarthritis and Cartilage  Volume 21, Issue 12, Pages (December 2013) DOI: /j.joca Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 Metabolic inflammation in MPS disease. IL-1 – interleukin 1β
Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 A) and (B). Radiographs of pelvis from patients with JIA (A) and MPS VI (B). (A) Asymmetrical sacroiliac joint space: widening of the right space, irregularity, subchondrial erosions, and sclerosis of the right sacroiliac joint. Narrowing of hip joint space. (B) Rounded iliac wings, dysplastic femoral heads, severe hip dysplasia. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

4 Fig. 3 A) and (B). Radiographs of hands from patients with JIA (A) and MPS VI (B). (A) Proximal interphalangeal (PIP) joint swelling (II P, II L, III L), contracture of PIP joints (V P), Narrowing of metacarpophalangeal (MCP), PIP and wrist joints Spacesta. Joint destruction: geodes and erosions of MCP joints (III P, I P, III L), wrist (L and P), and radial-carpal joints (L and P). (B) Claw hand deformity: bullet-shaped phalanges, thickened, short, metacarpal bones with proximal pointing and thin cortices, irregular carpal bones, irregular, broad radial and ulnar epiphysis, distal interphalangeal joint contractures. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions


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