1. Models of the Lungs and Interpretation of 3D Deposition Data
Ted Martonen, Ph.D.
National Health and Environmental Effects Research Laboratory
Department of Medicine, University of North Carolina at Chapel Hill

2. Overview
The efficacies of inhaled pharmacologic drugs may be improved if targeted to appropriate sites within the human respiratory system
The spatial deposition patterns of particles can be detected using SPECT and PET imaging
The effectiveness of such laboratory regimens has been limited by the inability of clinical investigators to clearly identify airway composition and particle deposition within the images

42. Conclusions
Using imaging (e.g. MRI) data we can unambiguously define the surfaces of left and right lungs
These customized lungs can be subdivided into a series of nested shells
The composition of the shells can be determined from the network model by airway number, airway type, airway surface area or airway volume
Deposition of an inhaled aerosol can be calculated within these shells, thus predicting the spatial distribution of an inhaled pharmacologic drug in a manner useful to clinical investigators
Future investigations will make use of patient-specific branching models bounded by MRI-derived lung surface models

43. Jeffrey Schroeter, CIIT
Acknowledgements
John Fleming, SGH
Dongming Hwang, IBM
Kristin Isaacs, UNC
Jeffrey Schroeter, CIIT