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Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers  Thierry Duvauchelle, MD, Philippe.

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Presentation on theme: "Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers  Thierry Duvauchelle, MD, Philippe."— Presentation transcript:

1 Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers  Thierry Duvauchelle, MD, Philippe Robert, PhD, Yves Donazzolo, MD, Sabrina Loyau, PharmD, Bernard Orlandini, MSc, Philippe Lehert, PhD, Jeanne-Marie Lecomte, PhD, Jean-Charles Schwartz, PhD  The Journal of Allergy and Clinical Immunology: In Practice  Volume 6, Issue 4, Pages (July 2018) DOI: /j.jaip Copyright © 2017 The Authors Terms and Conditions

2 Figure 1 Ultrasonographic images of the skin of a normal weight male subject before (left) and after (right) injection of 0.3 mg adrenaline using the Anapen autoinjector. The dotted lines and letter A denote the skin limit (left) or the bolus localization (right). The Journal of Allergy and Clinical Immunology: In Practice 2018 6, DOI: ( /j.jaip ) Copyright © 2017 The Authors Terms and Conditions

3 Figure 2 Ultrasonographic images of the skin of an overweight female subject before (left) and after (right) injection of 0.3 mg adrenaline using the Anapen autoinjector. The dotted line and letter A denote the skin limit (left) or the bolus localization (right). The Journal of Allergy and Clinical Immunology: In Practice 2018 6, DOI: ( /j.jaip ) Copyright © 2017 The Authors Terms and Conditions

4 Figure 3 Changes in adrenaline plasma levels and HR according to various conditions. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, DOI: ( /j.jaip ) Copyright © 2017 The Authors Terms and Conditions


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