1. A PASport to Cellular Proliferation
Eitan Zlotorynski, Reuven Agami 
Cell 
Volume 134, Issue 2, Pages (July 2008)
DOI: /j.cell
Copyright © 2008 Elsevier Inc. Terms and Conditions

2. Figure 1
Impact of mRNA Polyadenylation on Posttranscriptional Regulation
(A) Alternative polyadenylation sites. Top: alternative splicing of terminal exons (3′ exon switching); bottom: multiple polyadenylation sites along the same terminal exon (tandem 3′ untranslated regions [3′UTRs]).
(B) Changes in polyadenylation site usage can control the impact of a miRNA. Full-length 3′UTRs contain more target sequences for the binding of miRNA-induced silencing complexes (miRISC). Therefore, switching expression from a full-length 3′UTR to a shorter 3′UTR may make the mRNA no longer subject to regulation by particular miRNAs.
(C) RNA-binding proteins (RBPs) might also affect polyadenylation site usage in specific cellular conditions. For example, RBP binding to the polyadenylation site might render the mRNA inaccessible to polyadenylation factors.
Cell  , DOI: ( /j.cell )
Copyright © 2008 Elsevier Inc. Terms and Conditions