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A Radical Role for TOR in Longevity

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Presentation on theme: "A Radical Role for TOR in Longevity"— Presentation transcript:

1 A Radical Role for TOR in Longevity
Dudley W. Lamming, David M. Sabatini  Cell Metabolism  Volume 13, Issue 6, Pages (June 2011) DOI: /j.cmet Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Rapamycin Promotes Yeast Chronological Life Span
Rapamycin treatment of a yeast culture (top) during the logarithmic growth phase increases mitochondrial respiration and the generation of reactive oxygen species, resulting in the induction of cellular defense mechanisms that protect the yeast and will preserve viability during stationary phase. In contrast, an untreated yeast culture (bottom) experiences less oxidative stress during logarithmic growth and is unprepared for the harsh environment of stationary phase. Figure by Tom DiCesare, Whitehead Institute. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2011 Elsevier Inc. Terms and Conditions


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