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Hiding in Plain Sight: How Cancer Evades the Immune System

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Presentation on theme: "Hiding in Plain Sight: How Cancer Evades the Immune System"— Presentation transcript:

1 Hiding in Plain Sight: How Cancer Evades the Immune System

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4 Cancer Immunoediting Elimination➛ Equilibrium➛ Escape

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14 Proinflammatory Reaction Within the Tumor Microenvironment

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19 Tumor Cell-Mediated Immune Escape Aberrant Signal 1, 2, or 3 in the Tumor Microenvironment

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23 Tumor Cell-Mediated Immune Escape Providing an Aberrant Signal 2

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25 Control of the T Cell

26 Activating and Inhibitory Receptors

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28 CTLA4 in Immune Cell Deactivation

29 Anti-CTLA4 Antibody in Immune Cell Activation

30 Ipilimumab-Derived Rashes

31 The Immune Synapse

32 PD-1/PD-L1 in the Immune Response

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38 Concluding Remarks

39 Abbreviations

40 Abbreviations (cont)

41 Abbreviations (cont)

42 Abbreviations (cont)

43 Abbreviations (cont)


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